RFC2

This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]

Description

Replication factor C subunit 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (74231499 - 74254458)

Ensembl ID

ENSG00000049541  (ver. 103.38)

Orthologs

Mouse Rfc2: ENSMUSG00000023104

UniProt

P35250

neXtProt

NX_P35250

Human splice variants
Mouse splice variants

Protein structure