BS1987

antibody from Bioworld Technology, Inc
Targeting: TCF7 TCF-1
Provider product page for BS1987
Western blot
Immunohistochemistry

Antibody data

Product number
BS1987 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1987, RRID:AB_1663295
Product name
TCF 1 (F26) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids N-terminus of Human TCF-1.
Description
T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. Several alternative splice variants of TCF-1 have been identified, including TCF-1A, which share a conserved amino terminus and differ in the carboxy terminal sequences. The Wnt mediated signaling pathway induces cytosolic ÉÇ-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The ÉÇ-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates ÉÇ-catenin and, in turn, increases the degradation of cytosolic ÉÇ-catenin and inhibits the transcriptional activity of the TCF proteins.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TCF7 protein structure - BS1987 shown in red.