APR00048G

antibody from Leading Biology

Targeting: TNFRSF21 CD358, DR6

Western blot (Recommended by provider)

Antibody Data

Product number

APR00048G

Provider

Leading Biology

Product name

DR6 Antibody

Antibody type

Polyclonal

Description

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family thro μgh their death domain containing receptors, TNF-R1 and Fas. Several novel death receptor including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.