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- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Flow cytometry [1]
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- Product number
- 12-9875-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD367 (Clec4A, DCIR) Monoclonal Antibody (9E8), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This 9E8 monoclonal antibody reacts with human CD367, also known as dendritic cell immunoreceptor (DCIR) or Clec4A. This C-type lectin is expressed on monocytes, granulocytes, B cells, and plasmacytoid dendritic cells in peripheral blood. DCIR is also expressed on mature and immature monocyte-derived dendritic cells in vitro. DCIR is not expressed on NK or T cells. With its cytoplasmic ITIM domain, DCIR is an inhibitory receptor that recruits the SHP-1 and SHP-2 phosphatases upon ligand binding. Studies have demonstrated that DCIR plays a role in the interaction between dendritic cells and HIV-1.
- Conjugate
- Yellow dye
- Antibody clone number
- 9E8
- Concentration
- 5 µL/Test
Submitted references Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk.
DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway.
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.
The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways.
Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.
APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif.
El-Awady AR, Miles B, Scisci E, Kurago ZB, Palani CD, Arce RM, Waller JL, Genco CA, Slocum C, Manning M, Schoenlein PV, Cutler CW
PLoS pathogens 2015 Feb;10(2):e1004647
PLoS pathogens 2015 Feb;10(2):e1004647
DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway.
Lambert AA, Barabé F, Gilbert C, Tremblay MJ
Blood 2011 Jun 16;117(24):6589-99
Blood 2011 Jun 16;117(24):6589-99
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.
Klechevsky E, Flamar AL, Cao Y, Blanck JP, Liu M, O'Bar A, Agouna-Deciat O, Klucar P, Thompson-Snipes L, Zurawski S, Reiter Y, Palucka AK, Zurawski G, Banchereau J
Blood 2010 Sep 9;116(10):1685-97
Blood 2010 Sep 9;116(10):1685-97
The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways.
Lambert AA, Gilbert C, Richard M, Beaulieu AD, Tremblay MJ
Blood 2008 Aug 15;112(4):1299-307
Blood 2008 Aug 15;112(4):1299-307
Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.
Meyer-Wentrup F, Benitez-Ribas D, Tacken PJ, Punt CJ, Figdor CG, de Vries IJ, Adema GJ
Blood 2008 Apr 15;111(8):4245-53
Blood 2008 Apr 15;111(8):4245-53
APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif.
Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S
Journal of immunology (Baltimore, Md. : 1950) 1999 Aug 15;163(4):1973-83
Journal of immunology (Baltimore, Md. : 1950) 1999 Aug 15;163(4):1973-83
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD19 APC (Product # 17-0199-42) and 0.25 µg of Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (left) or 0.25 µg of Anti-Human CD367 (Clec4A, DCIR) PE (right). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Yellow dye
