CABT-B11944

antibody from Creative Diagnostics

Targeting: CLEC4A CD367, CLECSF6, DCIR, DDB27

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-B11944

Provider

Creative Diagnostics

Product name

Human anti-Human DCIR recombinant monoclonal antibody, clone SFB430 [FITC]

Antibody type

Monoclonal

Description

It recognozes the human dendritic cell immunoreceptor (DCIR) antigen, a single-pass type II membrane protein with a single carbohydrate recognition domain which is also known as C-type lectin domain family 4 member A (CLEC4A) or lectin-like immunoreceptor (LLIR). DCIR is expressed on dendritic cells (DCs), monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. It is mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34+ progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-\u03b1. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation. Additional information: It displays negligible binding to Fc receptors.

Reactivity

Human

Host

Human

Conjugate

Green dye

Isotype

IgG

Antibody clone number

SFB430

Vial size

for 100 tests

Storage

Store protected from light at 2ÿ8 °C. Do not freeze.