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- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Flow cytometry [1]
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- Product number
- 507607 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#507607, RRID:AB_2264898
- Product name
- Alexa Fluor® 647 anti-human IL-9 [MH9A4]
- Antibody type
- Monoclonal
- Antigen
- Baculovirus-expressed, recombinant human IL-9
- Description
- IL-9 is a potent, T cell-derived, T cell growth factor which can also enhance mast cell activity and IL-3- or IL-4- dependent proliferation of bone marrow-derived mast cells. IL-9 synergizes with erythropoietin to promote erythroid colony formation. IL-9 has also been reported to protect human T cells from apoptosis induced by IL-2 withdrawal. IL-9 is upregulated in human eosinophils by TNF-α and IL1-β. IL-9 has been reported to downregulate the oxidative burst in activated human alveolar macropahges and induce TGF-β production. The MH9A4 antibody reacts with human IL-9. The MH9A4 antibody can neutralize the bioactivity of natural or recombinant IL-9.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.
Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism.
Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH
Nature immunology 2010 Jun;11(6):527-34
Nature immunology 2010 Jun;11(6):527-34
Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism.
Chen J, Petrus M, Bryant BR, Phuc Nguyen V, Stamer M, Goldman CK, Bamford R, Morris JC, Janik JE, Waldmann TA
Blood 2008 May 15;111(10):5163-72
Blood 2008 May 15;111(10):5163-72
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- BioLegend (provider)
- Main image
- Experimental details
- PMA/ionomycin-stimulated TH2 polarized lymphocytes intracellularly stained with anti-CD3 (UCHT1) PE and MH9A4 Alexa Fluor® 647
- Conjugate
- Red dye
