60037

antibody from STEMCELL Technologies Inc

Targeting: ITGA6 CD49f

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

60037

Provider

STEMCELL Technologies Inc

Product name

Anti-Mouse CD49f Antibody, Clone GoH3

Antibody type

Monoclonal

Description

The GoH3 antibody reacts with CD49f (integrin ?6), an ~150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin ?1) or CD104 (integrin ?4) to form the heterodimeric receptors VLA-6 and ?6?4, which bind the extracellular matrix protein laminin. CD49f is a disulfide-linked dimer comprising an ~120 kDa heavy chain and an ~30 kDa membrane-bound light chain. Splice variants exist, which affect the cytoplasmic domain of the protein. CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial, and endothelial cells. It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of pluripotency of stem cells. CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells. The GoH3 antibody reacts with an extracellular epitope on CD49f and reportedly blocks integrin ?6 function in vivo and binding of integrin ?6 to laminin in vitro.

Reactivity

Human, Mouse, Bovine, Rabbit

Isotype

IgG

Vial size

100 µg

Storage

2 - 8°C