BS6154

antibody from Bioworld Technology, Inc
Targeting: ARHGEF7 BETA-PIX, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Provider product page for BS6154
Western blot
Immunohistochemistry

Antibody data

Product number
BS6154 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ARHGEF7 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human ARHGEF7.
Description
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, Ï« and ÉÇ, and both are highly expressed in heart, muscle and thymus tissues of human and rat. Ï«PIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The Ï«PIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ARHGEF7 protein structure - BS6154 shown in red.