BS6154
antibody from Bioworld Technology, Inc
Targeting: ARHGEF7
BETA-PIX, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS6154 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- ARHGEF7 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human ARHGEF7.
- Description
- The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, Ï« and ÉÇ, and both are highly expressed in heart, muscle and thymus tissues of human and rat. Ï«PIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The Ï«PIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- WesternBlot (WB) analysis of ARHGEF7 pAb in extracts from Jurkat, COS1, COS7, MCF7, K562 cells and mouse lung, heart tissues.