Antibody data

Product number
346902
Provider
BioLegend
Proper citation
BioLegend Cat#346902, RRID:AB_2028550
Product name
Purified anti-human Jagged 2
Provider product page
BioLegend - 346902
Antibody type
Monoclonal
Antigen
Human Jagged2-transfected CHO cells
Description
The binding of Notch ligands with their receptors results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect target cells. The Jagged-2 is one of the several Notch ligands identified. It is a single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL (Delta-Serrate-Lag-2) domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). Jagged 2 is expressed on lymphoma cells and some other tumor cells. Jagged-2 is reported to be essential for the regulation of spermatogenesis. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate, T cells and B cells to differentiate.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4 °C.
Provider Type Product Number
- No reagents -