DMAB9569

antibody from Creative Diagnostics

Targeting: ITGA7

No application information provided.

Antibody Data

Product number

DMAB9569

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DMAB9569, RRID:AB_2393113

Product name

Anti-Integrin Alpha 7 Monoclonal antibody, clone H1B4

Antibody type

Monoclonal

Description

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

Reactivity

Chicken/Avian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

H1B4

Vial size

1 ea