BS8052

antibody from Bioworld Technology, Inc
Targeting: IL12RB1 CD212, IL12RB
Provider product page for BS8052
Western blot
Immunohistochemistry

Antibody data

Product number
BS8052 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL12RB1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IL12RB1.
Description
IL-12, a heterodimeric cytokine composed of two disulfide-bonded glycoprotein subunits, p35 and p40, has pleiotrophic activities including stimulation of the proliferation of activated T and NK cells, induction of IFN-g production by PBMCs, enhancement of the lytic activity of NK/LAK cells and promotion of T-helper (Th) 1 cell responses. The T cell response to IL-12 is mediated through two receptor proteins, designated IL-12Rb-1 and IL-12Rb-2 (4). The genes encoding human IL-12Rb-1 and IL-12Rb-2 map to chromosomes 19p13.1 and 1p31.3-p31.2, respectively. Increased IL-12Rb-2 expression is crucial in regulating Th1 differentiation, whereas IL-12Rb-1 expression is less restricted. Inhibition of IL-12 activity may provide treatment for diseases associated with pathologic Th1 responses, such as multiple sclerosis or Crohn£ªs disease, while administration of recombinant IL-12 may aid in the treatment for allergic disorders and asthma.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL12RB1 protein structure - BS8052 shown in red.