Ab121783

antibody from Aladdin Scientific Corporation

Targeting: PIK3R2 p85, P85B

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab121783

Provider

Aladdin Scientific Corporation

Product name

Recombinant PI 3 Kinase p85 beta Antibody

Antibody type

Recombinant

Description

Rabbit anti Human PIK3R2 Antibody, Recombinant (R06-5H3), could be used for WB, IHC and so on.Application:WB: 1/500-1/1000IHC: 1/50-1/100Protein FunctionRegulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.

Reactivity

Human, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 140-164


Antibody clone number

R06-5H3

Vial size

100μl,10μl,1ml,50μl

Concentration

1,5 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.