Antibody data
- Antibody Data
- Antigen structure
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- Product number
- NBP2-54431V - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal CD11c Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Blue dye
- Isotype
- IgG
- Vial size
- 100 ul
- Storage
- Store at 4C in the dark.
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