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Immunohistochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 301616 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#301616, RRID:AB_439736
- Product name
- LEAF™ Purified anti-human CD11c [3.9]
- Antibody type
- Monoclonal
- Antigen
- CD11c
- Description
- CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αX and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references Phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to intracellular adhesion molecule-1.
Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses.
CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity.
Asai A, Okajima F, Nakagawa K, Ibusuki D, Tanimura K, Nakajima Y, Nagao M, Sudo M, Harada T, Miyazawa T, Oikawa S
Journal of lipid research 2009 May;50(5):957-65
Journal of lipid research 2009 May;50(5):957-65
Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses.
Gurer C, Strowig T, Brilot F, Pack M, Trumpfheller C, Arrey F, Park CG, Steinman RM, Münz C
Blood 2008 Aug 15;112(4):1231-9
Blood 2008 Aug 15;112(4):1231-9
CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity.
Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, Staunton DE
Journal of leukocyte biology 2007 Jun;81(6):1395-403
Journal of leukocyte biology 2007 Jun;81(6):1395-403
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood granulocytes were stained with LEAF™ purified CD11c (clone 3.9) (filled histogram) or LEAF™ purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
- Conjugate
- Unconjugated
