CABT-B9213

antibody from Creative Diagnostics

Targeting: GOLGA5 golgin-84, GOLIM5, ret-II, rfg5

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9213

Provider

Creative Diagnostics

Product name

Mouse anti-Human Golgin-84 monoclonal antibody, clone 37/Hpmhjo-95

Antibody type

Monoclonal

Description

The Golgi apparatus is a complex and dynamic organelle that functions in protein sorting and modification. Numerous structural and regulatory proteins are involved in the budding, docking, and fusion of Golgi-directed vesicles. Golgin-84 is an integral membrane protein associated with the Golgi. Sequence analysis of the C-terminal region of Golgin-84 demonstrates a 14 residue region extending into the lumen of the Golgi, a membrane insertion sequence, and a Golgi retention signal. The large N-terminal cytoplasmic region contains a coiled-coil domain that is required for dimerization and two leucine zipper domains. Golgin-84 is ubiquitously expressed, but is abundant in testis. Golgin-84 has sequence homology to coiled-coil containing myosin family members and to several other Golgi proteins, including trans-Golgi p230 and gigantin. Trans-Golgi p230 has been implicated in the biogenesis of specific Golgi vesicles, while gigantin is implicated in the tethering of non-clathrin coated vesicles and in the anchoring of adjacent Golgi cisternae. Thus, Golgin-84 may have similar roles in vesicle biogenesis, docking, and fusion at the Golgi interface.

Reactivity

Human, Canine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

37/Hpmhjo-95

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.