MB0169

antibody from Bioworld Technology, Inc

Targeting: CRTC1 FLJ14027, KIAA0616, MECT1, TORC1

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

MB0169

Provider

Bioworld Technology, Inc

Product name

TORC1 monoclonal antibody (Mouse IgM)

Antibody type

Monoclonal

Antigen

Recombinant full length Human TORC1.

Description

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 ¡ÉSer-133¡É phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.

Reactivity

Human, Mouse, Rat, Simian

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Western blot

Supportive validation

Submitted by

Bioworld Technology, Inc (provider)

Main image

Experimental details

Western blot detection of TORC1 mAb in Hela, mouse brain, SW480, COS7, C6 and 3T3 cell lysates using TORC1 mAb (1:2000 diluted) .