BS8189

antibody from Bioworld Technology, Inc

Targeting: PTPRN IA-2, ICA512

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8189

Provider

Bioworld Technology, Inc

Product name

PTPRN polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human PTPRN.

Description

Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins,membrane-associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPÏ«, PTPÉÇ, PTPÎÛ, PTPÑ´, PTPš÷, PTPšø, PTP°Ù and PTPÃ×. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTP IA-2 (PTP insulinoma-associated protein 2), also known as PTPRN, IA2, ICA512 (islet cell antigen 512) or RPTPN, is a receptor-type PTP-like protein containing a transmembrane region, an intracellular PTP-like domain and an extracellular Nterminus.Localizing to secretory granules, PTP IA-2 is exclusively expressed in neuroendocrine cells (including pancreatic islet cells) and is believed to participate in the regulation of secretory granule exocytosis. PTP IA-2 is an autoantigen and contributes to Insulin-dependent diabetes mellitus (IDDM). The detection of autoantibodies against PTP IA-2 is commonly used as a diabetes diagnosis marker.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.