BS6836

antibody from Bioworld Technology, Inc
Targeting: UPF1 HUPF1, KIAA0221, NORF1, pNORF1, RENT1, smg-2
Provider product page for BS6836
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6836 - Provider product page
Provider
Bioworld Technology, Inc
Product name
UPF1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human UPF1.
Description
Upf1 was identified as an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons. Upf1 was found to be an ATP-dependent RNA helicase in the cytoplasm and was later shown to be a component of cytoplasmic P-bodies. Upf1 phosphorylation mediates the repression of translation that accompanies NMD, allowing mRNA accessibility to the NMD machinery. Two other active components of NMD, Upf2 and Upf3, were also identified and described as having perinuclear and nucleocytoplasmic localization, respectively.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
UPF1 protein structure - BS6836 shown in red.