BS7943

antibody from Bioworld Technology, Inc
Targeting: FBXO11 FBX11, UBR6
Provider product page for BS7943
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7943 - Provider product page
Provider
Bioworld Technology, Inc
Product name
FBXO11 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human FBXO11.
Description
F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I°ÙB-Ï« and ÉÇ-catenin, for proteasomal degradation. FBXO11 (F-box only protein 11), also known as VIT1 (vitiligoassociated protein 1), is a 927 amino acid nuclear protein that contains one UBR-type zinc finger, one F-box domain and 19 PbH1 repeats. Involved in protein ubiquitination, FBXO11 functions as a substrate recognition component of the SCF complex and is thought to bind to and inhibit the transcriptional activity of p53. Reduced expression of FBXO11 is associated with vitiligo, a disease characterized by progressive skin depigmentation. Multiple isoforms of FBXO11 exist due to alternative splicing events.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FBXO11 protein structure - BS7943 shown in red.