Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 12275-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12275-1-AP, RRID:AB_2225096
- Product name
- AGR2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AGR2 antibody (Cat. #12275-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung.
Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers.
Ellagic acid alleviates TNBS-induced intestinal barrier dysfunction by regulating mucin secretion and maintaining tight junction integrity in rats.
Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells.
AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.
Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection.
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.
Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes.
Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study.
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
Identification and prognostic value of anterior gradient protein 2 expression in breast cancer based on tissue microarray.
Unique recurrence patterns of cervical intraepithelial neoplasia after excision of the squamocolumnar junction.
Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions.
A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia.
A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.
Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach.
Martins LR, Sieverling L, Michelhans M, Schiller C, Erkut C, Grünewald TGP, Triana S, Fröhling S, Velten L, Glimm H, Scholl C
Nature communications 2024 Mar 12;15(1):2246
Nature communications 2024 Mar 12;15(1):2246
Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers.
Liu B, Li S, Cheng Y, Song P, Xu M, Li Z, Shao W, Xin J, Fu Z, Gu D, Du M, Zhang Z, Wang M
Cell reports. Medicine 2024 Jun 18;5(6):101589
Cell reports. Medicine 2024 Jun 18;5(6):101589
Ellagic acid alleviates TNBS-induced intestinal barrier dysfunction by regulating mucin secretion and maintaining tight junction integrity in rats.
Peng B, Xue L, Yu Q, Zhong T
International journal of food sciences and nutrition 2023;74(4):476-486
International journal of food sciences and nutrition 2023;74(4):476-486
Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells.
Wang Z, Li Y, Zhao W, Jiang S, Huang Y, Hou J, Zhang X, Zhai Z, Yang C, Wang J, Zhu J, Pan J, Jiang W, Li Z, Ye M, Tan M, Jiang H, Dang Y
Signal transduction and targeted therapy 2023 May 1;8(1):175
Signal transduction and targeted therapy 2023 May 1;8(1):175
AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.
Sheng N, Wang YQ, Wang CF, Jia MQ, Niu HM, Lu QQ, Wang YN, Feng D, Zheng XX, Yuan HQ
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916
Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection.
Gurumurthy RK, Koster S, Kumar N, Meyer TF, Chumduri C
Nature protocols 2022 Jul;17(7):1658-1690
Nature protocols 2022 Jul;17(7):1658-1690
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Fang J, Zhang Z, Cheng Y, Yang H, Zhang H, Xue Z, Lu S, Dong Y, Song C, Zhang X, Zhou Y
Food & function 2022 Apr 20;13(8):4399-4420
Food & function 2022 Apr 20;13(8):4399-4420
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.
Chumduri C, Gurumurthy RK, Berger H, Dietrich O, Kumar N, Koster S, Brinkmann V, Hoffmann K, Drabkina M, Arampatzi P, Son D, Klemm U, Mollenkopf HJ, Herbst H, Mangler M, Vogel J, Saliba AE, Meyer TF
Nature cell biology 2021 Feb;23(2):184-197
Nature cell biology 2021 Feb;23(2):184-197
Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes.
Kanno A, Asahara SI, Kawamura M, Furubayashi A, Tsuchiya S, Suzuki E, Takai T, Koyanagi-Kimura M, Matsuda T, Okada Y, Ogawa W, Kido Y
Journal of diabetes investigation 2019 May;10(3):577-590
Journal of diabetes investigation 2019 May;10(3):577-590
Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study.
Negi H, Merugu SB, Mangukiya HB, Li Z, Zhou B, Sehar Q, Kamle S, Yunus FU, Mashausi DS, Wu Z, Li D
Cancer letters 2019 May 1;449:125-134
Cancer letters 2019 May 1;449:125-134
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, Tavernier J, Hrstka R, Dupont A, Fessart D, Delom F, Fernandez-Zapico ME, Jansen G, Eriksson LA, Thomas DY, Jerome-Majewska L, Hupp T, Chatziioannou A, Chevet E, Ogier-Denis E
EMBO molecular medicine 2019 Jun;11(6)
EMBO molecular medicine 2019 Jun;11(6)
Identification and prognostic value of anterior gradient protein 2 expression in breast cancer based on tissue microarray.
Guo J, Gong G, Zhang B
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317713392
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317713392
Unique recurrence patterns of cervical intraepithelial neoplasia after excision of the squamocolumnar junction.
Herfs M, Somja J, Howitt BE, Suarez-Carmona M, Kustermans G, Hubert P, Doyen J, Goffin F, Kridelka F, Crum CP, Delvenne P
International journal of cancer 2015 Mar 1;136(5):1043-52
International journal of cancer 2015 Mar 1;136(5):1043-52
Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions.
Herfs M, Parra-Herran C, Howitt BE, Laury AR, Nucci MR, Feldman S, Jimenez CA, McKeon FD, Xian W, Crum CP
The American journal of surgical pathology 2013 Sep;37(9):1311-8
The American journal of surgical pathology 2013 Sep;37(9):1311-8
A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia.
Herfs M, Vargas SO, Yamamoto Y, Howitt BE, Nucci MR, Hornick JL, McKeon FD, Xian W, Crum CP
The Journal of pathology 2013 Feb;229(3):460-8
The Journal of pathology 2013 Feb;229(3):460-8
A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.
Herfs M, Yamamoto Y, Laury A, Wang X, Nucci MR, McLaughlin-Drubin ME, Münger K, Feldman S, McKeon FD, Xian W, Crum CP
Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 26;109(26):10516-21
Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 26;109(26):10516-21
Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach.
Xue H, Lü B, Zhang J, Wu M, Huang Q, Wu Q, Sheng H, Wu D, Hu J, Lai M
Journal of proteome research 2010 Jan;9(1):545-55
Journal of proteome research 2010 Jan;9(1):545-55
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse stomach tissue were subjected to SDS PAGE followed by western blot with 12275-1-AP(AGR2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AGR2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AGR2. This antibody recognizes human,mouse,rat antigen. The AGR2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.