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- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 15753-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15753-1-AP, RRID:AB_2200485
- Product name
- TRBP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRBP antibody (Cat. #15753-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Loss of TARBP2 Drives the Progression of Hepatocellular Carcinoma via miR-145-SERPINE1 Axis.
Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells.
Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Amyloid peptide exerts a rapid induction of Dicer1 protein in neuron via reducing phosphorylation.
Evidence of A Negative Feedback Network Between TDP-43 and miRNAs Dependent on TDP-43 Nuclear Localization.
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.
FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.
A biosensor for MAPK-dependent Lin28 signaling.
A Rapid Induction Mechanism for Lin28a in Trophic Responses.
S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells.
The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection.
SUMOylation of TARBP2 regulates miRNA/siRNA efficiency.
Li LM, Chen C, Ran RX, Huang JT, Sun HL, Zeng C, Zhang Z, Zhang W, Liu SM
Frontiers in oncology 2021;11:620912
Frontiers in oncology 2021;11:620912
Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells.
Zhang H, Zhao X, Guo Y, Chen R, He J, Li L, Qiang Z, Yang Q, Liu X, Huang C, Lu R, Fang J, Cao Y, Huang J, Wang Y, Huang J, Chen GQ, Cheng J, Yu J
Nature communications 2021 Sep 13;12(1):5416
Nature communications 2021 Sep 13;12(1):5416
Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.
He Y, Huang M, Tang C, Yue Y, Liu X, Zheng Z, Dong H, Liu D
Virus research 2021 Jun;298:198404
Virus research 2021 Jun;298:198404
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Amyloid peptide exerts a rapid induction of Dicer1 protein in neuron via reducing phosphorylation.
Wang Y, Xiu X, Wu S
Neurochemistry international 2021 Dec;151:105210
Neurochemistry international 2021 Dec;151:105210
Evidence of A Negative Feedback Network Between TDP-43 and miRNAs Dependent on TDP-43 Nuclear Localization.
Hawley ZCE, Campos-Melo D, Strong MJ
Journal of molecular biology 2020 Dec 4;432(24):166695
Journal of molecular biology 2020 Dec 4;432(24):166695
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.
Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H
Molecular cell 2019 Sep 5;75(5):967-981.e9
Molecular cell 2019 Sep 5;75(5):967-981.e9
FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.
Ringeard M, Marchand V, Decroly E, Motorin Y, Bennasser Y
Nature 2019 Jan;565(7740):500-504
Nature 2019 Jan;565(7740):500-504
A biosensor for MAPK-dependent Lin28 signaling.
Oldach LM, Gorshkov K, Mills WT 4th, Zhang J, Meffert MK
Molecular biology of the cell 2018 May 15;29(10):1157-1167
Molecular biology of the cell 2018 May 15;29(10):1157-1167
A Rapid Induction Mechanism for Lin28a in Trophic Responses.
Amen AM, Ruiz-Garzon CR, Shi J, Subramanian M, Pham DL, Meffert MK
Molecular cell 2017 Feb 2;65(3):490-503.e7
Molecular cell 2017 Feb 2;65(3):490-503.e7
S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells.
Warner MJ, Bridge KS, Hewitson JP, Hodgkinson MR, Heyam A, Massa BC, Haslam JC, Chatzifrangkeskou M, Evans GJ, Plevin MJ, Sharp TV, Lagos D
Nucleic acids research 2016 Nov 16;44(20):9942-9955
Nucleic acids research 2016 Nov 16;44(20):9942-9955
The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection.
Komuro A, Homma Y, Negoro T, Barber GN, Horvath CM
Biochemical and biophysical research communications 2016 Nov 11;480(2):187-193
Biochemical and biophysical research communications 2016 Nov 11;480(2):187-193
SUMOylation of TARBP2 regulates miRNA/siRNA efficiency.
Chen C, Zhu C, Huang J, Zhao X, Deng R, Zhang H, Dou J, Chen Q, Xu M, Yuan H, Wang Y, Yu J
Nature communications 2015 Nov 19;6:8899
Nature communications 2015 Nov 19;6:8899
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 15753-1-AP(TRBP antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TARBP2 antibody 15753-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 15753-1-AP(TRBP antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 15753-1-AP(TRBP antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
