Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8382 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- RGS3 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human RGS3.
- Description
- Heterotrimeric G proteins function to relay information from cell surface receptors to various intracellular effectors. G proteins comprise a, b and g subunits, and following activation, the a subunit binds GTP and dissociates from the bg complex. A large group of proteins have been identified as GTPase-activating proteins (GAPs), including the RGS (regulator of G protein signaling) family, which serve to deactivate specific Ga isoforms by increasing the rate at which they convert GTP to GDP. RGS3 is a protein of the RGS family that preferentially binds to the activated form of Ga11. Through this association, RGS3 inhibits Ga11-induced signaling, leading to a decrease in the accumulation of intracellular calcium and the inhibition of MAP kinase phosphorylation. RGS3 is highly expressed in adult kidney and myocardium, and it is primarily localized to the cytoplasm. Upon activation of Ga11, RGS3 translocates from the cytosol to the plasma membrane, thereby bringing RGS3 within close proximity to the targeted G protein.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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