Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
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Validation data
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- Product number
- AF1048 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal HAI-1/HGFA Inhibitor 1 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human HAI-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse HAI-1 is observed and less than 1% cross-reactivity with recombinant human HAI-2 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Promoter Hypomethylation Is Responsible for Upregulated Expression of HAI-1 in Hepatocellular Carcinoma.
Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.
Matrix metalloproteinase-7 induces homotypic tumor cell aggregation via proteolytic cleavage of the membrane-bound Kunitz-type inhibitor HAI-1.
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development.
Du X, Wu L, Ur Rahman MS, Teng X, Teng L, Ye J, Cao J
Disease markers 2019;2019:9175215
Disease markers 2019;2019:9175215
Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.
Murray AS, Varela FA, Hyland TE, Schoenbeck AJ, White JM, Tanabe LM, Todi SV, List K
The Journal of biological chemistry 2017 Sep 8;292(36):14867-14884
The Journal of biological chemistry 2017 Sep 8;292(36):14867-14884
Matrix metalloproteinase-7 induces homotypic tumor cell aggregation via proteolytic cleavage of the membrane-bound Kunitz-type inhibitor HAI-1.
Ishikawa T, Kimura Y, Hirano H, Higashi S
The Journal of biological chemistry 2017 Dec 15;292(50):20769-20784
The Journal of biological chemistry 2017 Dec 15;292(50):20769-20784
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.
Buzza MS, Martin EW, Driesbaugh KH, Désilets A, Leduc R, Antalis TM
The Journal of biological chemistry 2013 Apr 12;288(15):10328-37
The Journal of biological chemistry 2013 Apr 12;288(15):10328-37
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development.
Szabo R, Molinolo A, List K, Bugge TH
Oncogene 2007 Mar 8;26(11):1546-56
Oncogene 2007 Mar 8;26(11):1546-56
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human HAI-1 by Simple WesternTM. Detection of Human HAI-1 by Simple WesternTM.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human HAI-1 by Western Blot. Detection of Human HAI-1 by Western Blot.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- HAI-1 in Human Lung Cancer Tissue. HAI-1 in Human Lung Cancer Tissue.