14937-1-AP

antibody from Proteintech Group

Targeting: SLC22A12 OAT4L, RST, URAT1

Provider product page for 14937-1-AP

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ELISA

Antibody data

Antibody Data
Antigen structure
References [32]
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Validations
Western blot [1]

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Product number: 14937-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14937-1-AP, RRID:AB_2191270
Product name: URAT1 antibody
Antibody type: Polyclonal
Description: KD/KO validated URAT1 antibody (Cat. #14937-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, pig, rat and has been validated for the following applications: WB,ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC22A12 protein structure - 14937-1-AP shown in red.

Submitted references Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model.

Li Q, Huang Z, Liu D, Zheng J, Xie J, Chen J, Zeng H, Su Z, Li Y
Drug design, development and therapy 2021;15:3241-3254

Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.

Xu L, Lin G, Yu Q, Li Q, Mai L, Cheng J, Xie J, Liu Y, Su Z, Li Y
Frontiers in pharmacology 2021;12:645879

Low Expression Levels of SLC22A12 Indicates a Poor Prognosis and Progresses Clear Cell Renal Cell Carcinoma.

Xu J, Liu Y, Liu J, Shou Y, Xiong Z, Xiong H, Xu T, Wang Q, Liu D, Liang H, Yang H, Yang X, Zhang X
Frontiers in oncology 2021;11:659208

Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats.

Qi X, Chen H, Guan K, Wang R, Ma Y
Journal of the science of food and agriculture 2021 Sep;101(12):4916-4924

Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice.

Zhang CL, Zhang JJ, Zhu QF, Guan HY, Yang YX, He X, Fu Y, Chen TX, Dong L, Yang XS, Tang KF, Xu GB, Liao SG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153765

Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.

Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600

Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice.

Zhu JX, Yang HY, Hu WQ, Cheng J, Liu Y, Yi LT, Cheng HY
Inflammopharmacology 2021 Aug;29(4):1187-1200

Resveratrol affects the expression of uric acid transporter by improving inflammation.

Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)

Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway.

Chang YH, Chiang YF, Chen HY, Huang YJ, Wang KL, Hong YH, Ali M, Shieh TM, Hsia SM
Antioxidants (Basel, Switzerland) 2021 Apr 6;10(4)

Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats.

Kang L, Miao JX, Cao LH, Miao YY, Miao MS, Liu HJ, Xiang LL, Song YG
Journal of ethnopharmacology 2020 Oct 28;261:113054

Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.

Wang Y, Kong W, Wang L, Zhang T, Huang B, Meng J, Yang B, Xie Z, Zhou H
International journal of molecular sciences 2020 Oct 18;21(20)

The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.

Wang G, Zuo T, Li R
Drug development research 2020 Nov;81(7):859-866

Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals.

Niu Y, Yang P, Li H, Li Q, Lin H, Gao L, Li L
Biological & pharmaceutical bulletin 2020 Nov 1;43(11):1653-1659

RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.

Liu N, Wang Y, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Li Y, Sun H, Yang M, Sun J, Yang X
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151

Discovery of a novel rice-derived peptide with significant anti-gout potency.

Liu N, Meng B, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Yang M, Wang Y, Yang X
Food & function 2020 Dec 1;11(12):10542-10553

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice.

Xu WH, Wang HT, Sun Y, Xue ZC, Liang ML, Su WK
The Journal of pharmacy and pharmacology 2020 Apr;72(4):551-560

Effects of Alismatis Rhizoma and Rhizoma Smilacis Glabrae Decoction on Hyperuricemia in Rats.

Cheng S, Sun H, Li X, Yan J, Peng Z, You Y, Zhang L, Chen J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:4541609

Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice.

Bao R, Liu M, Wang D, Wen S, Yu H, Zhong Y, Li Z, Zhang Y, Wang T
Frontiers in pharmacology 2019;10:1464

MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.

Zhou Z, Dong Y, Zhou H, Liu J, Zhao W
Biochemical and biophysical research communications 2019 Sep 24;517(3):413-420

Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition.

Lin H, Tu C, Niu Y, Li F, Yuan L, Li N, Xu A, Gao L, Li L
European journal of pharmacology 2019 Jun 15;853:371-380

Preventive Effects of Fucoidan and Fucoxanthin on Hyperuricemic Rats Induced by Potassium Oxonate.

Chau YT, Chen HY, Lin PH, Hsia SM
Marine drugs 2019 Jun 10;17(6)

Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes.

Zhang B, Duan M, Long B, Zhang B, Wang D, Zhang Y, Chen J, Huang X, Jiao Y, Zhu L, Zeng X
Molecular medicine reports 2019 Aug;20(2):1645-1654

Cordycepin, a Characteristic Bioactive Constituent in Cordyceps militaris, Ameliorates Hyperuricemia through URAT1 in Hyperuricemic Mice.

Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, Jiao C, Zuo D
Frontiers in microbiology 2018;9:58

Hypouricemic Effects of Extracts From Agrocybe aegerita on Hyperuricemia Mice and Virtual Prediction of Bioactives by Molecular Docking.

Yong T, Chen S, Xie Y, Shuai O, Li X, Chen D, Su J, Jiao C, Liang Y
Frontiers in pharmacology 2018;9:498

Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.

Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, Hu H, Zuo D, Liang D
The American journal of Chinese medicine 2018;46(3):585-599

Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9.

Zhou Y, Zhang X, Li C, Yuan X, Han L, Li Z, Tan X, Song J, Wang G, Jia X, Feng L, Qiao X, Liu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:434-442

Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson's disease.

Bao LH, Zhang YN, Zhang JN, Gu L, Yang HM, Huang YY, Xia N, Zhang H
Journal of neuroinflammation 2018 May 2;15(1):131

Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9.

Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, Jiao C, Zuo D
Frontiers in pharmacology 2017;8:996

Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis.

Zhang HJ, Li LN, Zhou J, Yang QQ, Liu PG, Xu P, Liang WQ, Cheng L, Zhang YQ, Pu JB, Hu YJ
Journal of ethnopharmacology 2017 May 5;203:304-311

Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model.

Jiang Y, Lin Y, Hu YJ, Song XJ, Pan HH, Zhang HJ
BMC complementary and alternative medicine 2017 Jun 17;17(1):320

Taurine decreased uric acid levels in hyperuricemic rats and alleviated kidney injury.

Feng Y, Sun F, Gao Y, Yang J, Wu G, Lin S, Hu J
Biochemical and biophysical research communications 2017 Jul 29;489(3):312-318

Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy.

Wu X, Zhang J, Liu T, Yan M, Liu H, Xie H, Zhang S, Sun B, Ke B, Zhou H
Journal of physiology and biochemistry 2015 Jun;71(2):217-26

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The URAT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human URAT1. This antibody recognizes human,mouse,rat antigen. The URAT1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14937-1-AP.pdf

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