Tissue expression
Cell line expression
Protein structure
SELENOK
Selenoprotein KSELK
The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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Proteintech Group | 12561-1-AP | 3 references | Polyclonal |
WB
EL |
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Atlas Antibodies | HPA008196 | Polyclonal |
WB
ICC
IHC
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Invitrogen Antibodies | PA5-34420 | 1 references | Polyclonal |
WB
IHC |
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antibodies-online | ABIN4352481 | Polyclonal |
WB
ICC
IHC
|
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GeneTex | GTX32088 | Polyclonal |
WB
ICC
IHC
|
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