BS2307

antibody from Bioworld Technology, Inc

Targeting: CBFB PEBP2B

Immunocytochemistry

Immunohistochemistry

Antibody data

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Validation data

Product number: BS2307 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS2307, RRID:AB_1663539
Product name: PEBP2ÉÇ (R33) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 2-56 of Human PEBP2ÉÇ.
Description: The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, Ï« and ÉÇ, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2Ï« subunits, PEBP2Ï«A, PEBP2Ï«B and PEBP2Ï«C, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory ÉÇ subunit, which facilitates DNA binding of the Ï« subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

CBFB protein structure - BS2307 shown in red.