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antibody from antibodies-online
Targeting: MEN1
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- Antibody Data
- Antigen structure
- References [26]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- ABIN151584 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Multiple Endocrine Neoplasia 1 (MEN1) (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- C-Term
- Vial size
- 100 μL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references The negative feedback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the "Knudson's second hit".
Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors.
Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation.
Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.
Tumor suppressor menin mediates peripheral nerve injury-induced neuropathic pain through potentiating synaptic plasticity.
Insulin regulates menin expression, cytoplasmic localization, and interaction with FOXO1.
MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases.
Regulation of cyclin B2 expression and cell cycle G2/m transition by menin.
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice.
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
Somatostatin stimulates menin gene expression by inhibiting protein kinase A.
NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations.
Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.
JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells.
Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice.
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.
Interaction of MLL amino terminal sequences with menin is required for transformation.
p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.
Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.
Menin links estrogen receptor activation to histone H3K4 trimethylation.
Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression.
Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Luzi E, Marini F, Giusti F, Galli G, Cavalli L, Brandi ML
PloS one 2012;7(6):e39767
PloS one 2012;7(6):e39767
Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors.
Agarwal SK, Jothi R
PloS one 2012;7(5):e37952
PloS one 2012;7(5):e37952
Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation.
Niu J, Mei F, Wang L, Liu S, Tian Y, Mo W, Li H, Lu QR, Xiao L
Glia 2012 Sep;60(9):1427-36
Glia 2012 Sep;60(9):1427-36
Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.
Veniaminova NA, Hayes MM, Varney JM, Merchant JL
American journal of physiology. Gastrointestinal and liver physiology 2012 Sep 15;303(6):G752-64
American journal of physiology. Gastrointestinal and liver physiology 2012 Sep 15;303(6):G752-64
Tumor suppressor menin mediates peripheral nerve injury-induced neuropathic pain through potentiating synaptic plasticity.
Xu S, Wu H, Wang X, Shen X, Guo X, Shen R, Wang F
Neuroscience 2012 Oct 25;223:473-85
Neuroscience 2012 Oct 25;223:473-85
Insulin regulates menin expression, cytoplasmic localization, and interaction with FOXO1.
Wuescher L, Angevine K, Hinds T, Ramakrishnan S, Najjar SM, Mensah-Osman EJ
American journal of physiology. Endocrinology and metabolism 2011 Sep;301(3):E474-83
American journal of physiology. Endocrinology and metabolism 2011 Sep;301(3):E474-83
MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases.
Corbo V, Dalai I, Scardoni M, Barbi S, Beghelli S, Bersani S, Albarello L, Doglioni C, Schott C, Capelli P, Chilosi M, Boninsegna L, Becker KF, Falconi M, Scarpa A
Endocrine-related cancer 2010 Sep;17(3):771-83
Endocrine-related cancer 2010 Sep;17(3):771-83
Regulation of cyclin B2 expression and cell cycle G2/m transition by menin.
Wu T, Zhang X, Huang X, Yang Y, Hua X
The Journal of biological chemistry 2010 Jun 11;285(24):18291-300
The Journal of biological chemistry 2010 Jun 11;285(24):18291-300
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice.
Shen HC, Ylaya K, Pechhold K, Wilson A, Adem A, Hewitt SM, Libutti SK
Endocrinology 2010 Aug;151(8):4024-30
Endocrinology 2010 Aug;151(8):4024-30
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK
Cancer research 2009 Mar 1;69(5):1858-66
Cancer research 2009 Mar 1;69(5):1858-66
Somatostatin stimulates menin gene expression by inhibiting protein kinase A.
Mensah-Osman E, Zavros Y, Merchant JL
American journal of physiology. Gastrointestinal and liver physiology 2008 Oct;295(4):G843-54
American journal of physiology. Gastrointestinal and liver physiology 2008 Oct;295(4):G843-54
NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations.
Gatta R, Mantovani R
Nucleic acids research 2008 Nov;36(20):6592-607
Nucleic acids research 2008 Nov;36(20):6592-607
Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.
La P, Yang Y, Karnik SK, Silva AC, Schnepp RW, Kim SK, Hua X
The Journal of biological chemistry 2007 Oct 26;282(43):31332-40
The Journal of biological chemistry 2007 Oct 26;282(43):31332-40
JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells.
Hock TD, Liby K, Wright MM, McConnell S, Schorpp-Kistner M, Ryan TM, Agarwal A
The Journal of biological chemistry 2007 Mar 2;282(9):6875-86
The Journal of biological chemistry 2007 Mar 2;282(9):6875-86
Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice.
Loffler KA, Biondi CA, Gartside MG, Serewko-Auret MM, Duncan R, Tonks ID, Mould AW, Waring P, Muller HK, Kay GF, Hayward NK
Oncogene 2007 Jun 7;26(27):4009-17
Oncogene 2007 Jun 7;26(27):4009-17
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K
The Journal of biological chemistry 2007 Jul 13;282(28):20395-406
The Journal of biological chemistry 2007 Jul 13;282(28):20395-406
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.
Demers C, Chaturvedi CP, Ranish JA, Juban G, Lai P, Morle F, Aebersold R, Dilworth FJ, Groudine M, Brand M
Molecular cell 2007 Aug 17;27(4):573-84
Molecular cell 2007 Aug 17;27(4):573-84
Interaction of MLL amino terminal sequences with menin is required for transformation.
Caslini C, Yang Z, El-Osta M, Milne TA, Slany RK, Hess JL
Cancer research 2007 Aug 1;67(15):7275-83
Cancer research 2007 Aug 1;67(15):7275-83
p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.
Pei XH, Bai F, Smith MD, Xiong Y
Cancer research 2007 Apr 1;67(7):3162-70
Cancer research 2007 Apr 1;67(7):3162-70
Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.
MacConaill LE, Hughes CM, Rozenblatt-Rosen O, Nannepaga S, Meyerson M
Molecular cancer research : MCR 2006 Oct;4(10):793-801
Molecular cancer research : MCR 2006 Oct;4(10):793-801
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.
Ji H, Zhao X, Yuza Y, Shimamura T, Li D, Protopopov A, Jung BL, McNamara K, Xia H, Glatt KA, Thomas RK, Sasaki H, Horner JW, Eck M, Mitchell A, Sun Y, Al-Hashem R, Bronson RT, Rabindran SK, Discafani CM, Maher E, Shapiro GI, Meyerson M, Wong KK
Proceedings of the National Academy of Sciences of the United States of America 2006 May 16;103(20):7817-22
Proceedings of the National Academy of Sciences of the United States of America 2006 May 16;103(20):7817-22
Menin links estrogen receptor activation to histone H3K4 trimethylation.
Dreijerink KM, Mulder KW, Winkler GS, Höppener JW, Lips CJ, Timmers HT
Cancer research 2006 May 1;66(9):4929-35
Cancer research 2006 May 1;66(9):4929-35
Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression.
La P, Desmond A, Hou Z, Silva AC, Schnepp RW, Hua X
Oncogene 2006 Jun 15;25(25):3537-46
Oncogene 2006 Jun 15;25(25):3537-46
Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.
Schnepp RW, Chen YX, Wang H, Cash T, Silva A, Diehl JA, Brown E, Hua X
Cancer research 2006 Jun 1;66(11):5707-15
Cancer research 2006 Jun 1;66(11):5707-15
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.
Yokoyama A, Somervaille TC, Smith KS, Rozenblatt-Rosen O, Meyerson M, Cleary ML
Cell 2005 Oct 21;123(2):207-18
Cell 2005 Oct 21;123(2):207-18
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS, Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF, Hayward NK, Hess JL, Meyerson M
Molecular cell 2004 Feb 27;13(4):587-97
Molecular cell 2004 Feb 27;13(4):587-97
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