CABT-L1255

antibody from Creative Diagnostics

Targeting: CTCF CFAP108, FAP108

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Chromatin Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-L1255

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human CTCF monoclonal antibody, clone H.869.5

Antibody type

Monoclonal

Description

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. A molecular weight of approximately 140 kDa is expected.

Reactivity

Human, Mouse, Rat, Bovine, Horse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

H.869.5

Storage

-20°C