Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-L1255 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Rabbit Anti-Human CTCF monoclonal antibody, clone H.869.5
- Antibody type
- Monoclonal
- Description
- This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. A molecular weight of approximately 140 kDa is expected.
- Reactivity
- Human, Mouse, Rat, Bovine, Horse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- H.869.5
- Storage
- -20°C
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