Antibody data

Product number
BS2643
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS2643, RRID:AB_1914358
Product name
Topo IIÏ« (E1102) polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS2643
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 1071-1220 of Human Topo IIÏ«.
Description
DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIÏ« and Topo IIÉÇ.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Provider Type Product Number
- No reagents -