Antibody data

Product number
10-7577
Provider
ABEOMICS Inc.
Product name
Anti-Topo II alpha Antibody
Provider product page
ABEOMICS Inc. - 10-7577
Antibody type
Monoclonal
Description
Topoisomerases are essential nuclear enzymes that are involved in DNA supercoiling regulation and play key roles in transcription, replication, and chromosome segregation. Two major classes of topoisomerases (types I and II) are distinguished by the number of DNA strands that they cleave and the mechanism by which they alter the topological properties of DNA. Topo II Alpha is cell cycle-regulated and is essential for the survival of proliferating cells. It accumulates on chromatin during M-phase, a dynamic localization that is dependent on its C-terminal domain. Although Topo II alpha is the major form of Topo II responsible for decatenation, mitotic chromosome formation and chromosome segregation in proliferating cells, the contribution of the two isoforms has not yet been fully established. Topo II Alpha plays an important role in DNA synthesis and transcription and has been implicated in a variety of human cancers. It also plays a role in various cancer subtypes and acts as targets for cancer therapy, as well as biomarkers for prediction of response.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant human
Topo II alpha protein (amino acids
1326-1512) was used as the immunoge
n for this antibody.
Isotype
IgG
Antibody clone number
ABM48B4
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
Provider Type Product Number
- No reagents -