11-8031-25

antibody from ABEOMICS Inc.
Targeting: TFG FLJ36137, SPG57, TF6
Provider product page for 11-8031-25

Antibody data

Product number
11-8031-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-TRK Fused gene Antibody
Antibody type
Polyclonal
Description
TRK Fused gene (TFG) encodes a protein that plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. It is a conserved regulator of protein secretion that assembles into an oligomeric matrix at the interface between the ER and ER Golgi intermediate compartments in metazoans cells. Originally TFG was identified as a fusion partner of the NTRK1 gene in human papillary thyroid carcinoma. It is also involved in another chromosome translocation with the ALK gene in anaplastic large-cell lymphomas. It is located on the q arm of human chromosome 3 and encodes a ubiquitously expressed cytoplasmic protein. Structural analysis reveals TFG containing a coiled-coil (CC) domain and a serine, proline, tyrosine, glycine and glutamine (SPYGQ)-rich region. Interestingly, the TFG protein interacts with the NF-kappaB essential modulator and TRAF family member-associated NF-kappaB activator proteins, suggesting that it may play a key role in NF-kappaB regulation.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant TRK Fu
sed gene protein (amino acids 196-4
00) was used as the immunogen for t
his antibody.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
TFG protein structure - 11-8031-25 shown in red.