BS6398

antibody from Bioworld Technology, Inc
Targeting: MAX bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8
Provider product page for BS6398
Western blot
Immunocytochemistry

Antibody data

Product number
BS6398 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MAX (phospho S11) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human MAX around the phosphorylation site of Serine 11.
Description
It is now well established that the nature and relative abundance of individual subunits of different classes of transcription factors can positively or negatively regulate levels of gene expression. Myc proteins homodimerize and bind DNA poorly, if at all, at physiological levels. Max is a nuclear localized bHLH-Zip protein initially identified by screening a B cell expression library with the bHLH-Zip region of c-Myc. Max homodimers and the Myc-Max heterodimers bind the sequence CACGTG; however the binding of the hetero-dimeric complex is stronger than the Max homodimer. The Max gene products have been identified as Max and Max 9 proteins that differ by a 9 amino acid insertion N-terminal to the basic region. In contrast to Myc, which is highly regulated during progression through the cell cycle, Max is highly stable and is much more abundant than Myc. Two members of the bHLH-Zip protein family, designated Mad and Mxi1, homodimerize poorly but form heterodimeric complexes with Max that have opposing functions to Myc-Max heterodimers with respect to regulation of gene expression.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MAX protein structure - BS6398 shown in red.