Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 12949-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12949-1-AP, RRID:AB_2161499
- Product name
- PDK4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PDK4 antibody (Cat. #12949-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Prostaglandin E1 attenuates AngII-induced cardiac hypertrophy via EP3 receptor activation and Netrin-1upregulation.
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.
Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells.
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.
Effects of Dietary Fat Restriction on Endurance Training-induced Metabolic Adaptations in Rat Skeletal Muscle.
Dietary Olive Oil Intake Improves Running Endurance with Intramuscular Triacylglycerol Accumulation in Mice.
Difference in pyruvic acid metabolism between neonatal and adult mouse lungs exposed to hyperoxia.
Loss of PDK4 expression promotes proliferation, tumorigenicity, motility and invasion of hepatocellular carcinoma cells.
Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki).
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.
Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China.
STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle.
Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer.
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle.
Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance.
Effects of functional β-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells.
AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming.
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
Enhancement of Glucose Metabolism via PGC-1α Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia.
MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice.
Effects of neonatal dexamethasone administration on cardiac recovery ability under ischemia-reperfusion in 24-wk-old rats.
AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.
Shen Y, Wang X, Yuan R, Pan X, Yang X, Cai J, Li Y, Yin A, Xiao Q, Ji Q, Li Y, He B, Shen L
Journal of molecular and cellular cardiology 2021 Oct;159:91-104
Journal of molecular and cellular cardiology 2021 Oct;159:91-104
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.
Christianto A, Baba T, Takahashi F, Inui K, Inoue M, Suyama M, Ono Y, Ohkawa Y, Morohashi KI
Communications biology 2021 Nov 4;4(1):1264
Communications biology 2021 Nov 4;4(1):1264
Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells.
Qi W, Xu Q, Xu Y, Wang Z, Yang L, Guo S, Shi Y, Zhao T, Zhou L, Ye L
Ecotoxicology and environmental safety 2021 Jan 15;208:111472
Ecotoxicology and environmental safety 2021 Jan 15;208:111472
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.
Song X, Liu J, Kuang F, Chen X, Zeh HJ 3rd, Kang R, Kroemer G, Xie Y, Tang D
Cell reports 2021 Feb 23;34(8):108767
Cell reports 2021 Feb 23;34(8):108767
Effects of Dietary Fat Restriction on Endurance Training-induced Metabolic Adaptations in Rat Skeletal Muscle.
Karasawa T, Kondo S, Fukazawa A, Koike A, Tsutsui M, Terada S
Journal of oleo science 2021 Feb 1;70(2):253-262
Journal of oleo science 2021 Feb 1;70(2):253-262
Dietary Olive Oil Intake Improves Running Endurance with Intramuscular Triacylglycerol Accumulation in Mice.
Komiya Y, Sugiyama M, Ochiai M, Osawa N, Adachi Y, Iseki S, Arihara K
Nutrients 2021 Apr 1;13(4)
Nutrients 2021 Apr 1;13(4)
Difference in pyruvic acid metabolism between neonatal and adult mouse lungs exposed to hyperoxia.
Tanaka K, Watanabe T, Ozawa J, Ito M, Nagano N, Arai Y, Miyake F, Matsumura S, Kobayashi S, Itakura R, Namba F
PloS one 2020;15(9):e0238604
PloS one 2020;15(9):e0238604
Loss of PDK4 expression promotes proliferation, tumorigenicity, motility and invasion of hepatocellular carcinoma cells.
Qin YJ, Lin TY, Lin XL, Liu Y, Zhao WT, Li XY, Lian M, Chen HW, Li YL, Zhang XL, Xiao D, Jia JS, Sun Y
Journal of Cancer 2020;11(15):4397-4405
Journal of Cancer 2020;11(15):4397-4405
Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki).
Lai N, Fealy CE, Kummitha CM, Cabras S, Kirwan JP, Hoppel CL
Frontiers in physiology 2020;11:677
Frontiers in physiology 2020;11:677
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059
Theranostics 2020;10(26):12044-12059
Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.
Liu Y, Sun L, Zheng L, Su M, Liu H, Wei Y, Li D, Wang Y, Dai C, Gong Y, Zhao C, Li Y
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Kľučková K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.
Wang L, Yu P, Zhou B, Song J, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S
Nature cell biology 2020 Jan;22(1):108-119
Nature cell biology 2020 Jan;22(1):108-119
Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.
Jonus HC, Byrnes CC, Kim J, Valle ML, Bartlett MG, Said HM, Zastre JA
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109648
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109648
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China.
Chen C, Luo F, Wu P, Huang Y, Das A, Chen S, Chen J, Hu X, Li F, Fang Z, Zhou S
Journal of cellular and molecular medicine 2020 Feb;24(4):2484-2496
Journal of cellular and molecular medicine 2020 Feb;24(4):2484-2496
STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Oberhuber M, Pecoraro M, Rusz M, Oberhuber G, Wieselberg M, Haslinger P, Gurnhofer E, Schlederer M, Limberger T, Lagger S, Pencik J, Kodajova P, Högler S, Stockmaier G, Grund-Gröschke S, Aberger F, Bolis M, Theurillat JP, Wiebringhaus R, Weiss T, Haitel A, Brehme M, Wadsak W, Griss J, Mohr T, Hofer A, Jäger A, Pollheimer J, Egger G, Koellensperger G, Mann M, Hantusch B, Kenner L
Molecular systems biology 2020 Apr;16(4):e9247
Molecular systems biology 2020 Apr;16(4):e9247
Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle.
Fukazawa A, Koike A, Karasawa T, Tsutsui M, Kondo S, Terada S
Nutrients 2020 Apr 30;12(5)
Nutrients 2020 Apr 30;12(5)
Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer.
Wang J, Qian Y, Gao M
Cancer management and research 2019;11:251-262
Cancer management and research 2019;11:251-262
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle.
Li Y, Pan H, Zhang X, Wang H, Liu S, Zhang H, Qian H, Wang L, Ying H
Journal of agricultural and food chemistry 2019 Apr 24;67(16):4483-4492
Journal of agricultural and food chemistry 2019 Apr 24;67(16):4483-4492
Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance.
Fekir K, Dubois-Pot-Schneider H, Désert R, Daniel Y, Glaise D, Rauch C, Morel F, Fromenty B, Musso O, Cabillic F, Corlu A
Cancer research 2019 Apr 15;79(8):1869-1883
Cancer research 2019 Apr 15;79(8):1869-1883
Effects of functional β-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells.
Li Y, Fan Y, Pan H, Qian H, Qi X, Wu G, Zhang H, Xu M, Rao Z, Wang L, Ying H
International journal of biological macromolecules 2018 Oct 1;117:287-293
International journal of biological macromolecules 2018 Oct 1;117:287-293
AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming.
Zhang P, Song Y, Sun Y, Li X, Chen L, Yang L, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3924-3935
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3924-3935
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
Liu X, Zuo R, Bao Y, Qu X, Sun K, Ying H
Scientific reports 2017 Aug 16;7(1):8474
Scientific reports 2017 Aug 16;7(1):8474
Enhancement of Glucose Metabolism via PGC-1α Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia.
Li X, Liu Y, Ma H, Guan Y, Cao Y, Tian Y, Zhang Y
Frontiers in physiology 2016;7:219
Frontiers in physiology 2016;7:219
MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice.
Lin X, Qin Y, Jia J, Lin T, Lin X, Chen L, Zeng H, Han Y, Wu L, Huang S, Wang M, Huang S, Xie R, Liang L, Liu Y, Liu R, Zhang T, Li J, Wang S, Sun P, Huang W, Yao K, Xu K, Du T, Xiao D
PLoS genetics 2016 Oct;12(10):e1006308
PLoS genetics 2016 Oct;12(10):e1006308
Effects of neonatal dexamethasone administration on cardiac recovery ability under ischemia-reperfusion in 24-wk-old rats.
Jiang X, Ma H, Li C, Cao Y, Wang Y, Zhang Y, Liu Y
Pediatric research 2016 Jul;80(1):128-35
Pediatric research 2016 Jul;80(1):128-35
AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
Kemmerer M, Finkernagel F, Cavalcante MF, Abdalla DS, Müller R, Brüne B, Namgaladze D
PloS one 2015;10(6):e0130893
PloS one 2015;10(6):e0130893
PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.
Strand DW, Jiang M, Murphy TA, Yi Y, Konvinse KC, Franco OE, Wang Y, Young JD, Hayward SW
Cell death & disease 2012 Aug 9;3:e361
Cell death & disease 2012 Aug 9;3:e361
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 12949-1-AP(PDK4 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 12949-1-AP(PDK4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDK4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDK4. This antibody recognizes human,mouse,rat antigen. The PDK4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.