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- Antibody Data
- Antigen structure
- References [17]
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- Western blot [3]
- Immunohistochemistry [2]
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- Product number
- ABIN2841206 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 382-410), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 382-410, C-Term
- Antibody clone number
- RB03041
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots.
- Handling
- Avoid freeze-thaw cycles.
Submitted references Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells.
Glucose oxidation modulates anoikis and tumor metastasis.
Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats.
Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects.
PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.
Adaptive gene regulation of pyruvate dehydrogenase kinase isoenzyme 4 in hepatotoxic chemical-induced liver injury and its stimulatory potential for DNA repair and cell proliferation.
Intrinsic protein kinase activity in mitochondrial oxidative phosphorylation complexes.
Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha).
Bezafibrate induces myotoxicity in human rhabdomyosarcoma cells via peroxisome proliferator-activated receptor alpha signaling.
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.
Regulation of the PDK4 isozyme by the Rb-E2F1 complex.
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress.
The STAT5A-mediated induction of pyruvate dehydrogenase kinase 4 expression by prolactin or growth hormone in adipocytes.
Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression.
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.
Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor.
Walter W, Thomalla J, Bruhn J, Fagan DH, Zehowski C, Yee D, Skildum A
SpringerPlus 2015;4:689
SpringerPlus 2015;4:689
Glucose oxidation modulates anoikis and tumor metastasis.
Kamarajugadda S, Stemboroski L, Cai Q, Simpson NE, Nayak S, Tan M, Lu J
Molecular and cellular biology 2012 May;32(10):1893-907
Molecular and cellular biology 2012 May;32(10):1893-907
Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats.
Williams DB, Wan Z, Frier BC, Bell RC, Field CJ, Wright DC
American journal of physiology. Regulatory, integrative and comparative physiology 2012 Jan 1;302(1):R49-58
American journal of physiology. Regulatory, integrative and comparative physiology 2012 Jan 1;302(1):R49-58
Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 24;109(17):6739-44
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 24;109(17):6739-44
Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects.
Long YC, Kostovski E, Boon H, Hjeltnes N, Krook A, Widegren U
Journal of applied physiology (Bethesda, Md. : 1985) 2011 May;110(5):1204-10
Journal of applied physiology (Bethesda, Md. : 1985) 2011 May;110(5):1204-10
PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.
Dunford EC, Herbst EA, Jeoung NH, Gittings W, Inglis JG, Vandenboom R, LeBlanc PJ, Harris RA, Peters SJ
American journal of physiology. Regulatory, integrative and comparative physiology 2011 Jun;300(6):R1487-93
American journal of physiology. Regulatory, integrative and comparative physiology 2011 Jun;300(6):R1487-93
Adaptive gene regulation of pyruvate dehydrogenase kinase isoenzyme 4 in hepatotoxic chemical-induced liver injury and its stimulatory potential for DNA repair and cell proliferation.
Dateki M, Kunitomo M, Yoshioka K, Yanai K, Nakasono S, Negishi T
Journal of receptor and signal transduction research 2011 Feb;31(1):85-95
Journal of receptor and signal transduction research 2011 Feb;31(1):85-95
Intrinsic protein kinase activity in mitochondrial oxidative phosphorylation complexes.
Phillips D, Aponte AM, Covian R, Balaban RS
Biochemistry 2011 Apr 5;50(13):2515-29
Biochemistry 2011 Apr 5;50(13):2515-29
Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha).
Attia RR, Connnaughton S, Boone LR, Wang F, Elam MB, Ness GC, Cook GA, Park EA
The Journal of biological chemistry 2010 Jan 22;285(4):2375-85
The Journal of biological chemistry 2010 Jan 22;285(4):2375-85
Bezafibrate induces myotoxicity in human rhabdomyosarcoma cells via peroxisome proliferator-activated receptor alpha signaling.
Zhao Y, Okuyama M, Hashimoto H, Tagawa Y, Jomori T, Yang B
Toxicology in vitro : an international journal published in association with BIBRA 2010 Feb;24(1):154-9
Toxicology in vitro : an international journal published in association with BIBRA 2010 Feb;24(1):154-9
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.
Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z
American journal of physiology. Heart and circulatory physiology 2009 Dec;297(6):H2096-108
American journal of physiology. Heart and circulatory physiology 2009 Dec;297(6):H2096-108
Regulation of the PDK4 isozyme by the Rb-E2F1 complex.
Hsieh MC, Das D, Sambandam N, Zhang MQ, Nahlé Z
The Journal of biological chemistry 2008 Oct 10;283(41):27410-7
The Journal of biological chemistry 2008 Oct 10;283(41):27410-7
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress.
Nahlé Z, Hsieh M, Pietka T, Coburn CT, Grimaldi PA, Zhang MQ, Das D, Abumrad NA
The Journal of biological chemistry 2008 May 23;283(21):14317-26
The Journal of biological chemistry 2008 May 23;283(21):14317-26
The STAT5A-mediated induction of pyruvate dehydrogenase kinase 4 expression by prolactin or growth hormone in adipocytes.
White UA, Coulter AA, Miles TK, Stephens JM
Diabetes 2007 Jun;56(6):1623-9
Diabetes 2007 Jun;56(6):1623-9
Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression.
Long YC, Glund S, Garcia-Roves PM, Zierath JR
The Journal of biological chemistry 2007 Jan 19;282(3):1607-14
The Journal of biological chemistry 2007 Jan 19;282(3):1607-14
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.
Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA
The Journal of biological chemistry 2006 Dec 29;281(52):39897-906
The Journal of biological chemistry 2006 Dec 29;281(52):39897-906
Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor.
Savkur RS, Bramlett KS, Michael LF, Burris TP
Biochemical and biophysical research communications 2005 Apr 1;329(1):391-6
Biochemical and biophysical research communications 2005 Apr 1;329(1):391-6
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