Antibody data

Product number
PA5-111779 - Provider product page
Provider
Invitrogen Antibodies
Product name
GPR43 (extracellular) Polyclonal Antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide
Description
Description: The eBioCB16 monoclonal antibody recognizes CD16 (Fc gammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (Fc gammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1, and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
50 µL
Concentration
0.8 mg/mL
Storage
-20°C
FFAR2 protein structure - PA5-111779 shown in red.