BS6326

antibody from Bioworld Technology, Inc
Targeting: ASAH1 AC, ACDase, ASAH, FLJ21558, PHP32
Provider product page for BS6326
Western blot
Immunohistochemistry

Antibody data

Product number
BS6326 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ASAH1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human ASAH1.
Description
Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ASAH1 protein structure - BS6326 shown in red.