Antibody data
- Antibody Data
- Antigen structure
- References [38]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [4]
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- Product number
- ABIN152648 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) (AA 1-50), (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- N-Term, AA 1-50
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references The effects of ceftriaxone on cue-primed reinstatement of cocaine-seeking in male and female rats: estrous cycle effects on behavior and protein expression in the nucleus accumbens.
Characterization of the cystine/glutamate antiporter in cultured Bergmann glia cells.
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.
Erythropoietin-induced cytoprotection in intestinal epithelial cells is linked to system Xc<sup/>.
Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression.
Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.
CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.
Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity.
The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain.
Alcohol consumption increases basal extracellular glutamate in the nucleus accumbens core of Sprague-Dawley rats without increasing spontaneous glutamate release.
Utility of [18F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population.
Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance.
Cystine/glutamate antiporter blockage induces myelin degeneration.
Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.
Effects of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats.
Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol.
Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11.
Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.
Lack of effect of Theiler's murine encephalomyelitis virus infection on system xc⁻.
Kaposi's Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis.
Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support.
IGF-I regulates redox status in breast cancer cells by activating the amino acid transport molecule xC-.
Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.
Early intraarticular injection of hyaluronic acid attenuates osteoarthritis progression in anterior cruciate ligament-transected rats.
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
The pharmacologic inhibition of the xc- antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis.
Inhibition of nonsense-mediated RNA decay activates autophagy.
(4S)-4-(3-18F-fluoropropyl)-L-glutamate for imaging of xC transporter activity in hepatocellular carcinoma using PET: preclinical and exploratory clinical studies.
Activated human CD4+ T cells express transporters for both cysteine and cystine.
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer.
Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir.
Astrocytic redox remodeling by amyloid beta peptide.
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity.
Glutamate, excitatory amino acid transporters, Xc- antiporter, glutamine synthetase, and gamma-glutamyltranspeptidase in human corneal epithelium.
Burn injury induces the expression of cystine/glutamate transporter (x(c)(-)) in mouse T cells.
Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin.
Bechard AR, Hamor PU, Schwendt M, Knackstedt LA
Psychopharmacology 2018 Mar;235(3):837-848
Psychopharmacology 2018 Mar;235(3):837-848
Characterization of the cystine/glutamate antiporter in cultured Bergmann glia cells.
Suárez-Pozos E, Martínez-Lozada Z, Méndez-Flores OG, Guillem AM, Hernández-Kelly LC, Castelán F, Olivares-Bañuelos TN, Chi-Castañeda D, Najimi M, Ortega A
Neurochemistry international 2017 Sep;108:52-59
Neurochemistry international 2017 Sep;108:52-59
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T
eLife 2017 Oct 2;6
eLife 2017 Oct 2;6
Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.
Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, Soya H, Ni J, Brichta L, Greengard P, Neve RL, Lee FS, McEwen BS
Neuron 2017 Oct 11;96(2):402-413.e5
Neuron 2017 Oct 11;96(2):402-413.e5
Erythropoietin-induced cytoprotection in intestinal epithelial cells is linked to system Xc<sup/>.
Martin C, Patel M, Melendez-Ferro M, Sims B
Experimental cell research 2017 Mar 15;352(2):202-206
Experimental cell research 2017 Mar 15;352(2):202-206
Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression.
LaCrosse AL, O'Donovan SM, Sepulveda-Orengo MT, McCullumsmith RE, Reissner KJ, Schwendt M, Knackstedt LA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Jun 14;37(24):5809-5821
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Jun 14;37(24):5809-5821
Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.
Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, Van Liefferinge J, Bentea E, Verbruggen L, Demuyser T, Deneyer L, Lewerenz J, van Loo G, De Keyser J, Sato H, Maher P, Methner A, Massie A
Journal of neuroinflammation 2017 Jan 13;14(1):9
Journal of neuroinflammation 2017 Jan 13;14(1):9
CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.
Bertaux-Skeirik N, Wunderlich M, Teal E, Chakrabarti J, Biesiada J, Mahe M, Sundaram N, Gabre J, Hawkins J, Jian G, Engevik AC, Yang L, Wang J, Goldenring JR, Qualls JE, Medvedovic M, Helmrath MA, Diwan T, Mulloy JC, Zavros Y
The Journal of pathology 2017 Aug;242(4):463-475
The Journal of pathology 2017 Aug;242(4):463-475
Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity.
Linher-Melville K, Nashed MG, Ungard RG, Haftchenary S, Rosa DA, Gunning PT, Singh G
PloS one 2016;11(8):e0161202
PloS one 2016;11(8):e0161202
The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain.
Slosky LM, BassiriRad NM, Symons AM, Thompson M, Doyle T, Forte BL, Staatz WD, Bui L, Neumann WL, Mantyh PW, Salvemini D, Largent-Milnes TM, Vanderah TW
Pain 2016 Nov;157(11):2605-2616
Pain 2016 Nov;157(11):2605-2616
Alcohol consumption increases basal extracellular glutamate in the nucleus accumbens core of Sprague-Dawley rats without increasing spontaneous glutamate release.
Pati D, Kelly K, Stennett B, Frazier CJ, Knackstedt LA
The European journal of neuroscience 2016 Jul;44(2):1896-905
The European journal of neuroscience 2016 Jul;44(2):1896-905
Utility of [18F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population.
Kavanaugh G, Williams J, Morris AS, Nickels ML, Walker R, Koglin N, Stephens AW, Washington MK, Geevarghese SK, Liu Q, Ayers D, Shyr Y, Manning HC
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2016 Dec;18(6):924-934
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2016 Dec;18(6):924-934
Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance.
Polewski MD, Reveron-Thornton RF, Cherryholmes GA, Marinov GK, Cassady K, Aboody KS
Molecular cancer research : MCR 2016 Dec;14(12):1229-1242
Molecular cancer research : MCR 2016 Dec;14(12):1229-1242
Cystine/glutamate antiporter blockage induces myelin degeneration.
Soria FN, Zabala A, Pampliega O, Palomino A, Miguelez C, Ugedo L, Sato H, Matute C, Domercq M
Glia 2016 Aug;64(8):1381-95
Glia 2016 Aug;64(8):1381-95
Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.
Van Liefferinge J, Bentea E, Demuyser T, Albertini G, Follin-Arbelet V, Holmseth S, Merckx E, Sato H, Aerts JL, Smolders I, Arckens L, Danbolt NC, Massie A
The Journal of comparative neurology 2016 Apr 1;524(5):1015-32
The Journal of comparative neurology 2016 Apr 1;524(5):1015-32
Effects of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats.
Aal-Aaboda M, Alhaddad H, Osowik F, Nauli SM, Sari Y
Journal of neuroscience research 2015 Jun;93(6):930-7
Journal of neuroscience research 2015 Jun;93(6):930-7
Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol.
Rao PS, Saternos H, Goodwani S, Sari Y
Psychopharmacology 2015 Jul;232(13):2333-42
Psychopharmacology 2015 Jul;232(13):2333-42
Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11.
Martin L, Gardner LB
Oncogene 2015 Aug 6;34(32):4211-8
Oncogene 2015 Aug 6;34(32):4211-8
Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.
Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 18;112(33):E4600-9
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 18;112(33):E4600-9
Lack of effect of Theiler's murine encephalomyelitis virus infection on system xc⁻.
Merckx E, Demuyser T, Bentea E, Van Liefferinge J, Albertini G, Deneyer L, Michiels T, Massie A
Neuroscience letters 2015 Apr 23;593:124-8
Neuroscience letters 2015 Apr 23;593:124-8
Kaposi's Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis.
Fontana JM, Mygatt JG, Conant KL, Parsons CH, Kaleeba JA
Journal of skin cancer 2014;2014:246076
Journal of skin cancer 2014;2014:246076
Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support.
Boutter J, Huang Y, Marovca B, Vonderheit A, Grotzer MA, Eckert C, Cario G, Wollscheid B, Horvath P, Bornhauser BC, Bourquin JP
Oncotarget 2014 Nov 30;5(22):11501-12
Oncotarget 2014 Nov 30;5(22):11501-12
IGF-I regulates redox status in breast cancer cells by activating the amino acid transport molecule xC-.
Yang Y, Yee D
Cancer research 2014 Apr 15;74(8):2295-305
Cancer research 2014 Apr 15;74(8):2295-305
Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.
Drayton RM, Dudziec E, Peter S, Bertz S, Hartmann A, Bryant HE, Catto JW
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Apr 1;20(7):1990-2000
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Apr 1;20(7):1990-2000
Early intraarticular injection of hyaluronic acid attenuates osteoarthritis progression in anterior cruciate ligament-transected rats.
Tsai WY, Wu JL, Liu CC, Cherng CH, Tsai RY, Jean YH, Wong CS
Connective tissue research 2013;54(1):49-54
Connective tissue research 2013;54(1):49-54
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW
Cancer cell 2013 Oct 14;24(4):450-65
Cancer cell 2013 Oct 14;24(4):450-65
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT
The Journal of biological chemistry 2013 Nov 22;288(47):33542-58
The Journal of biological chemistry 2013 Nov 22;288(47):33542-58
The pharmacologic inhibition of the xc- antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis.
Balza E, Castellani P, Delfino L, Truini M, Rubartelli A
Carcinogenesis 2013 Mar;34(3):620-6
Carcinogenesis 2013 Mar;34(3):620-6
Inhibition of nonsense-mediated RNA decay activates autophagy.
Wengrod J, Martin L, Wang D, Frischmeyer-Guerrerio P, Dietz HC, Gardner LB
Molecular and cellular biology 2013 Jun;33(11):2128-35
Molecular and cellular biology 2013 Jun;33(11):2128-35
(4S)-4-(3-18F-fluoropropyl)-L-glutamate for imaging of xC transporter activity in hepatocellular carcinoma using PET: preclinical and exploratory clinical studies.
Baek S, Mueller A, Lim YS, Lee HC, Lee YJ, Gong G, Kim JS, Ryu JS, Oh SJ, Lee SJ, Bacher-Stier C, Fels L, Koglin N, Schatz CA, Dinkelborg LM, Moon DH
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013 Jan;54(1):117-23
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013 Jan;54(1):117-23
Activated human CD4+ T cells express transporters for both cysteine and cystine.
Levring TB, Hansen AK, Nielsen BL, Kongsbak M, von Essen MR, Woetmann A, Odum N, Bonefeld CM, Geisler C
Scientific reports 2012;2:266
Scientific reports 2012;2:266
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer.
Baek S, Choi CM, Ahn SH, Lee JW, Gong G, Ryu JS, Oh SJ, Bacher-Stier C, Fels L, Koglin N, Hultsch C, Schatz CA, Dinkelborg LM, Mittra ES, Gambhir SS, Moon DH
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Oct 1;18(19):5427-37
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Oct 1;18(19):5427-37
Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir.
Ferrucci A, Nonnemacher MR, Cohen EA, Wigdahl B
Virus research 2012 Aug;167(2):358-69
Virus research 2012 Aug;167(2):358-69
Astrocytic redox remodeling by amyloid beta peptide.
Garg SK, Vitvitsky V, Albin R, Banerjee R
Antioxidants & redox signaling 2011 Jun 15;14(12):2385-97
Antioxidants & redox signaling 2011 Jun 15;14(12):2385-97
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity.
Zhang L, Gavin T, Barber DS, LoPachin RM
Toxicology letters 2011 Aug 10;205(1):1-7
Toxicology letters 2011 Aug 10;205(1):1-7
Glutamate, excitatory amino acid transporters, Xc- antiporter, glutamine synthetase, and gamma-glutamyltranspeptidase in human corneal epithelium.
Langford MP, Redmond P, Chanis R, Misra RP, Redens TB
Current eye research 2010 Mar;35(3):202-11
Current eye research 2010 Mar;35(3):202-11
Burn injury induces the expression of cystine/glutamate transporter (x(c)(-)) in mouse T cells.
D'Elia M, Patenaude J, Dupras C, Bernier J
Immunology letters 2009 Aug 15;125(2):137-44
Immunology letters 2009 Aug 15;125(2):137-44
Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin.
Liu R, Blower PE, Pham AN, Fang J, Dai Z, Wise C, Green B, Teitel CH, Ning B, Ling W, Lyn-Cook BD, Kadlubar FF, Sadée W, Huang Y
Molecular pharmacology 2007 Dec;72(6):1637-46
Molecular pharmacology 2007 Dec;72(6):1637-46
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