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Learn367904
antibody from BioLegend
Targeting: SCIMP
C17orf87, DTFT5783, FLJ32580, MGC163426, MGC163428, UNQ5783
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 367904 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#367904, RRID:AB_2566046
- Product name
- Alexa Fluor® 647 anti-human SCIMP
- Antibody type
- Monoclonal
- Antigen
- Recombinant intracellular part of human SCIMP.
- Description
- SCIMP, SLP adaptor and CSK interacting membrane protein, is a 17 kD palmitoylated transmembrane adaptor protein that is expressed in professional antigen presenting cells that are most prominent in the immunological synapse. It is associated with tetraspanin-enriched microdomains (together with MHC II). SCIMP is constitutively bound to tyrosine kinase Lyn by its SH3 domain. SCIMP becomes phosphorylated at several tyrosine residues after MHC II-mediated stimulations, which allows for downstream signaling by providing docking sites for Grb2, SLP65 or SLP76 adaptors, and the kinase CSK, as well.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Antibody clone number
- NVL-07
- Vial size
- 100 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes were surface stained with HLA-DR, DP, DQ FITC, and then were treated with True-Nuclear™ Transcription Factor Buffer Set. Cells were then stained with SCIMP (clone NVL-07) Alexa Fluor® 647 (top) or mouse IgG2a, κ Alexa Fluor® 647 isotype control (bottom).
- Conjugate
- Red dye
