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- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS9212 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CD272 (W153) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 120-176 of Human CD272.
- Description
- B and T lymphocyte attenuator (BTLA,CD272) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are co-inhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T cell activation by propagating inhibitory signals through BTLA. The BTLA-HVEM interaction is conserved between mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of CD272 pAb at 1:1000 dilution Lane1:THP-1 whole cell lysate(37ug) Lane2:The Spleen tissue lysate of Rat(32ug) Lane3:The Spleen tissue lysate of Mouse(36ug) Lane4:The peripheral blood cell lysateof Rat(36ug) Lane5:The peripheral blood cell lysate of Mouse(36ug)
