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- Antibody Data
- Antigen structure
- References [14]
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- Western blot [1]
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- Product number
- NB100-56352 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-56352, RRID:AB_2264237
- Product name
- Rabbit Polyclonal 5-HT7 Antibody
- Antibody type
- Polyclonal
- Description
- Protein G purified. This sequence is identical for 5-HT7R splice variants in the rat (5-HT7Ra/b/c), human (5-HT7Ra/b/d) and human 5-HT7, the mouse 5-HT7R. It is 93% conserved with dog 5-HT7Ra/b, and 81% conserved with pig 5-HT7R. The 5HT7 antibody recognizes all described 5HT7 receptor splice variants.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery.
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology.
Disruption to the 5-HT7 Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain.
Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.
The serotonin receptor 5-HT₇R regulates the morphology and migratory properties of dendritic cells.
Expression of the spinal 5-HT7 receptor and p-ERK pathway in the carrageenan inflammatory pain of rats.
Sensitization of restraint-induced corticosterone secretion after chronic restraint in rats: involvement of 5-HT₇ receptors.
Blockade of 5-HT7 receptors reduces tactile allodynia in the rat.
Biphasic regulation of mammary epithelial resistance by serotonin through activation of multiple pathways.
Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions.
Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor.
Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells.
Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines.
Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T, Yoshie O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A
Nature 2019 Jan;565(7738):246-250
Nature 2019 Jan;565(7738):246-250
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology.
Volpicelli F, Speranza L, Pulcrano S, De Gregorio R, Crispino M, De Sanctis C, Leopoldo M, Lacivita E, di Porzio U, Bellenchi GC, Perrone-Capano C
Molecular neurobiology 2019 Dec;56(12):8617-8627
Molecular neurobiology 2019 Dec;56(12):8617-8627
Disruption to the 5-HT7 Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain.
Wixey JA, Reinebrant HE, Chand KK, Buller KM
Neurochemical research 2018 Mar;43(3):711-720
Neurochemical research 2018 Mar;43(3):711-720
Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
Gautam J, Banskota S, Regmi SC, Ahn S, Jeon YH, Jeong H, Kim SJ, Nam TG, Jeong BS, Kim JA
Molecular cancer 2016 Nov 21;15(1):75
Molecular cancer 2016 Nov 21;15(1):75
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.
Speranza L, Giuliano T, Volpicelli F, De Stefano ME, Lombardi L, Chambery A, Lacivita E, Leopoldo M, Bellenchi GC, di Porzio U, Crispino M, Perrone-Capano C
Frontiers in behavioral neuroscience 2015;9:62
Frontiers in behavioral neuroscience 2015;9:62
The serotonin receptor 5-HT₇R regulates the morphology and migratory properties of dendritic cells.
Holst K, Guseva D, Schindler S, Sixt M, Braun A, Chopra H, Pabst O, Ponimaskin E
Journal of cell science 2015 Aug 1;128(15):2866-80
Journal of cell science 2015 Aug 1;128(15):2866-80
Expression of the spinal 5-HT7 receptor and p-ERK pathway in the carrageenan inflammatory pain of rats.
Cho SY, Ki HG, Kim JM, Oh JM, Yang JH, Kim WM, Lee HG, Yoon MH, Choi JI
Korean journal of anesthesiology 2015 Apr;68(2):170-4
Korean journal of anesthesiology 2015 Apr;68(2):170-4
Sensitization of restraint-induced corticosterone secretion after chronic restraint in rats: involvement of 5-HT₇ receptors.
García-Iglesias BB, Mendoza-Garrido ME, Gutiérrez-Ospina G, Rangel-Barajas C, Noyola-Díaz M, Terrón JA
Neuropharmacology 2013 Aug;71:216-27
Neuropharmacology 2013 Aug;71:216-27
Blockade of 5-HT7 receptors reduces tactile allodynia in the rat.
Amaya-Castellanos E, Pineda-Farias JB, Castañeda-Corral G, Vidal-Cantú GC, Murbartián J, Rocha-González HI, Granados-Soto V
Pharmacology, biochemistry, and behavior 2011 Oct;99(4):591-7
Pharmacology, biochemistry, and behavior 2011 Oct;99(4):591-7
Biphasic regulation of mammary epithelial resistance by serotonin through activation of multiple pathways.
Pai VP, Horseman ND
The Journal of biological chemistry 2008 Nov 7;283(45):30901-10
The Journal of biological chemistry 2008 Nov 7;283(45):30901-10
Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions.
Stull MA, Pai V, Vomachka AJ, Marshall AM, Jacob GA, Horseman ND
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 16;104(42):16708-13
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 16;104(42):16708-13
Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor.
León-Ponte M, Ahern GP, O'Connell PJ
Blood 2007 Apr 15;109(8):3139-46
Blood 2007 Apr 15;109(8):3139-46
Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells.
Mahé C, Loetscher E, Dev KK, Bobirnac I, Otten U, Schoeffter P
Neuropharmacology 2005 Jul;49(1):40-7
Neuropharmacology 2005 Jul;49(1):40-7
Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines.
Mahé C, Bernhard M, Bobirnac I, Keser C, Loetscher E, Feuerbach D, Dev KK, Schoeffter P
British journal of pharmacology 2004 Oct;143(3):404-10
British journal of pharmacology 2004 Oct;143(3):404-10
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: 5-HT7 Antibody [NB100-56352] - Analysis of 5-HT7R in A) human brain, B) mouse brain, C) rat brain, and D) human SK-N-SH neuroblastoma cell lysate using this antibody.
