BS6494

antibody from Bioworld Technology, Inc
Targeting: SIRT1 SIR2L1
Provider product page for BS6494
Western blot
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry
Chromatin Immunoprecipitation

Antibody data

Product number
BS6494 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SIRT1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SIRT1.
Description
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD+/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction.
Reactivity
Human, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SIRT1 protein structure - BS6494 shown in red.