BS7744

antibody from Bioworld Technology, Inc
Targeting: CPT1A CPT1, CPT1-L, L-CPT1
Provider product page for BS7744
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7744 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CPT1A polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CPT1A.
Description
The mitochondrial ÉÇ-oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase (CPT) I (outer membrane and detergent labile) and II (inner membrane and detergent stable), together with carnitine carrier. CPTI catalyzes the first reaction in the transport of long-chain fatty acids from the cytoplasm to the mitochondrion, a rate-limiting step in beta-oxidation. Two types of CPTI are known, the liver (CPTIA) and muscle (CPTIB) isoforms. The muscle type protein is specially expressed in heart and skeletal muscle. Membrane-bound CPTI, but not CPTII, is inhibited reversibly by malonyl-coenzyme A (CoA). Unlike CPTII, CPTI requires membrane integrity for catalytic function. In addition, glutamic acid 3 and histidine 5 are necessary for malonyl CoA inhibition and binding to liver CPTI, but not for catalytic activity.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CPT1A protein structure - BS7744 shown in red.