616802

antibody from BioLegend

Targeting: RARA NR1B1, RAR

Western blot (Data presented on provider website)

Chromatin Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

616802

Provider

BioLegend

Proper citation

BioLegend Cat#616802, RRID:AB_2177739

Product name

Purified anti-RARa

Antibody type

Polyclonal

Antigen

Recombinant (partial), N-terminal amino acids 1-100

Description

RARα (retinoic acid receptor alpha) is a 51 kD member of the nuclear hormone receptor family, NR1 subfamily. This nuclear protein contains modulating, DNA-binding, and steroid binding domains, and has been reported to have multiple isoforms. RARα is a nuclear receptor for retinoic acid that controls cell function by regulating gene expression and inducing profound effects on vertebrate development, acting as a morphogen and powerful teratogen. RARα is increased by protein kinase C stimulation, and estrogen; decreased at G0/G1 to S phase of cell cycle and in lymphocytes by cellular activation. RARα can be modified by phosphorylation and has been shown to interact with NCOA3 and NCOA6 co-activators leading to strong increases in the transcription of target genes. The Poly6168 antibody recognizes the N-terminal region of human RARα and has been shown to be useful for Western blotting.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

200 µl

Storage

Upon receipt, store frozen at -20° C.