CABT-Z363L

antibody from Creative Diagnostics

Targeting: TNS4 CTEN

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-Z363L

Provider

Creative Diagnostics

Product name

Recombinant Llama Anti-Human Tensin4 Monoclonal Antibody, clone Oc23

Antibody type

Monoclonal

Description

Tensin is a component of the cytoskeleton and localizes close to or at focal adhesions, connecting the cytoplasmic tail of integrins with actin filaments. It contains a C-terminal SH2 and PTB (phosphotyrosinebinding domain). It binds tyrosine-phosphorylated proteins that assemble into signaling complexes at focal adhesions. TNS4, or CTEN as it is also known, does not contain an N-terminal region with an actin binding domain unlike the other isoforms. TSN4 is reported to regulate cell motility and may affect metastasis of cancer cells. Its expression has been reported to be down regulated in prostate cancer, but upregulated in lung and breast cancer. The SH2 domain of CTEN was shown to bind directly to phosphorylated MET receptor, thus stabilizing the protein and preventing its degradation in lysosomes.

Reactivity

Human

Conjugate

Unconjugated

Antibody clone number

Oc23

Vial size

100 _g

Concentration

Lot specific

Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.