PA5-53456

antibody from Invitrogen Antibodies

Targeting: SLC19A2 THTR1, TRMA

Immunohistochemistry (Supportive data in Antibodypedia)

Other assay (Supportive data in Antibodypedia)

Antibody Data

Product number

PA5-53456

Provider

Invitrogen Antibodies

Product name

SLC19A2 Polyclonal Antibody

Antibody type

Polyclonal

Antigen

Recombinant full-length protein

Description

Immunogen sequence: RECWFLPTAL LCAYGFFASL RPSEPFLTPY LLGPDKNLTE REEPKPDRLL VLKVLWNDFL MCYSSR Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 62%.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100 µL

Concentration

0.1 mg/mL

Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

References

Submitted references

In situ molecular characterization of endoneurial microvessels that form the blood-nerve barrier in normal human adult peripheral nerves.

Ouyang X, Dong C, Ubogu EE
Journal of the peripheral nervous system : JPNS 2019 Jun;24(2):195-206

Immunohistochemistry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Immunohistochemical staining of SLC19A2 in human lung shows strong cytoplasmic positivity in macrophages. Samples were probed using a SLC19A2 Polyclonal Antibody (Product # PA5-53456).

Other assay

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Restrictive junctional complex and transporter proteins. Representative indirect fluorescent digital photomicrographs of cryostat axial sections of normal adult sural nerves show UEA-1-positive endothelial cells (green; A, E, I, M, Q, U) with expression of LIN7A, CDH5, CLDN4, VEZT, SLC16A1 and SLC19A2 (red; B, F, J, N, R, V, respectively) restricted to endoneurial microvessels shown in the merged images at lower and higher magnifications (yellow/ orange). LIN7A expression by endoneurial microvessels is apparent only at higher magnification (D). These proteins are expressed by the restrictive blood-nerve barrier and shared with other selected cell types suggesting specialized roles in the restrictive junctional complex formation (LIN7A, CDH5, CLDN4 and VEZT) or specialized nutrient transporters (SLC16A1 and SLC19A2) within normal adult peripheral nerves, as determined by known morphological profiles in situ. White arrows demonstrate positively staining endoneurial microvascular endothelium. Blue (4, 6-diamidino-2-phenylindole) staining indicates nuclei. Scale bar 500 mum for A-C, E-G, I-K, M-O, Q-S and U-W, and 125 mum for D, H, L, P, T and X