Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 305212 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#305212, RRID:AB_314508
- Product name
- LEAF™ Purified anti-human CD80 [2D10]
- Antibody type
- Monoclonal
- Antigen
- CD80
- Description
- CD80, also known as B7-1, B7, and BB1, is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. CD80 is expressed on activated B and T cells, macrophages, and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation. The interaction of CD80 with CD28 provides a potent costimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides an inhibitory signal for T cell activation.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references Self-reactive human CD4 T cell clones form unusual immunological synapses.
Leishmania major infection activates NF-kappaB and interferon regulatory factors 1 and 8 in human dendritic cells.
Schubert DA, Gordo S, Sabatino JJ Jr, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW
The Journal of experimental medicine 2012 Feb 13;209(2):335-52
The Journal of experimental medicine 2012 Feb 13;209(2):335-52
Leishmania major infection activates NF-kappaB and interferon regulatory factors 1 and 8 in human dendritic cells.
Jayakumar A, Donovan MJ, Tripathi V, Ramalho-Ortigao M, McDowell MA
Infection and immunity 2008 May;76(5):2138-48
Infection and immunity 2008 May;76(5):2138-48
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Daudi cells stained with 2D10 PE
- Conjugate
- Unconjugated