Explore
Validate
Learn
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN252648 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-TANK-Binding Kinase 1 (TBK1) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat, Bovine, Canine
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 108A429
- Vial size
- 0.1 mg
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Signalling strength determines proapoptotic functions of STING.
Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission.
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.
Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines.
Autophagy facilitates Salmonella replication in HeLa cells.
Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
IFN-β expression is directly activated in human neutrophils transfected with plasmid DNA and is further increased via TLR-4-mediated signaling.
Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction.
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.
Toll-like receptor 4 signal transduction in platelets: novel pathways.
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality.
Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1.
Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils.
Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation.
Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code.
The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4.
Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer.
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells.
IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines.
Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells.
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Gulen MF, Koch U, Haag SM, Schuler F, Apetoh L, Villunger A, Radtke F, Ablasser A
Nature communications 2017 Sep 5;8(1):427
Nature communications 2017 Sep 5;8(1):427
Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission.
Kwon D, Park E, Sesaki H, Kang SJ
Biochemical and biophysical research communications 2017 Nov 4;493(1):737-743
Biochemical and biophysical research communications 2017 Nov 4;493(1):737-743
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.
Slowicka K, Vereecke L, Mc Guire C, Sze M, Maelfait J, Kolpe A, Saelens X, Beyaert R, van Loo G
European journal of immunology 2016 Apr;46(4):971-80
European journal of immunology 2016 Apr;46(4):971-80
Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines.
Mukawera E, Chartier S, Williams V, Pagano PJ, Lapointe R, Grandvaux N
Redox biology 2015 Dec;6:9-18
Redox biology 2015 Dec;6:9-18
Autophagy facilitates Salmonella replication in HeLa cells.
Yu HB, Croxen MA, Marchiando AM, Ferreira RB, Cadwell K, Foster LJ, Finlay BB
mBio 2014 Mar 11;5(2):e00865-14
mBio 2014 Mar 11;5(2):e00865-14
Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):5216-25
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):5216-25
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86
IFN-β expression is directly activated in human neutrophils transfected with plasmid DNA and is further increased via TLR-4-mediated signaling.
Tamassia N, Bazzoni F, Le Moigne V, Calzetti F, Masala C, Grisendi G, Bussmeyer U, Scutera S, De Gironcoli M, Costantini C, Musso T, Cassatella MA
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 1;189(3):1500-9
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 1;189(3):1500-9
Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction.
Ogasawara N, Sasaki M, Itoh Y, Tokudome K, Kondo Y, Ito Y, Tanida S, Kamiya T, Kataoka H, Joh T, Kasugai K
Journal of clinical biochemistry and nutrition 2011 Mar;48(2):154-60
Journal of clinical biochemistry and nutrition 2011 Mar;48(2):154-60
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.
Joung SM, Park ZY, Rani S, Takeuchi O, Akira S, Lee JY
Journal of immunology (Baltimore, Md. : 1950) 2011 Jan 1;186(1):499-507
Journal of immunology (Baltimore, Md. : 1950) 2011 Jan 1;186(1):499-507
Toll-like receptor 4 signal transduction in platelets: novel pathways.
Berthet J, Damien P, Hamzeh-Cognasse H, Pozzetto B, Garraud O, Cognasse F
British journal of haematology 2010 Oct;151(1):89-92
British journal of haematology 2010 Oct;151(1):89-92
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality.
Marchlik E, Thakker P, Carlson T, Jiang Z, Ryan M, Marusic S, Goutagny N, Kuang W, Askew GR, Roberts V, Benoit S, Zhou T, Ling V, Pfeifer R, Stedman N, Fitzgerald KA, Lin LL, Hall JP
Journal of leukocyte biology 2010 Dec;88(6):1171-80
Journal of leukocyte biology 2010 Dec;88(6):1171-80
Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1.
Radtke AL, O'Riordan MX
Cellular microbiology 2008 Nov;10(11):2197-207
Cellular microbiology 2008 Nov;10(11):2197-207
Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils.
Tamassia N, Le Moigne V, Rossato M, Donini M, McCartney S, Calzetti F, Colonna M, Bazzoni F, Cassatella MA
Journal of immunology (Baltimore, Md. : 1950) 2008 Nov 1;181(9):6563-73
Journal of immunology (Baltimore, Md. : 1950) 2008 Nov 1;181(9):6563-73
Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation.
McCoy CE, Carpenter S, Pålsson-McDermott EM, Gearing LJ, O'Neill LA
The Journal of biological chemistry 2008 May 23;283(21):14277-85
The Journal of biological chemistry 2008 May 23;283(21):14277-85
Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code.
Merimi M, Klener P, Szynal M, Cleuter Y, Kerkhofs P, Burny A, Martiat P, Van den Broeke A
Journal of virology 2007 Jun;81(11):5929-39
Journal of virology 2007 Jun;81(11):5929-39
The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4.
Tamassia N, Le Moigne V, Calzetti F, Donini M, Gasperini S, Ear T, Cloutier A, Martinez FO, Fabbri M, Locati M, Mantovani A, McDonald PP, Cassatella MA
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 1;178(11):7344-56
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 1;178(11):7344-56
Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer.
Péant B, Diallo JS, Lessard L, Delvoye N, Le Page C, Saad F, Mes-Masson AM
Molecular cancer research : MCR 2007 Jan;5(1):87-94
Molecular cancer research : MCR 2007 Jan;5(1):87-94
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells.
Aksoy E, Albarani V, Nguyen M, Laes JF, Ruelle JL, De Wit D, Willems F, Goldman M, Goriely S
Blood 2007 Apr 1;109(7):2887-93
Blood 2007 Apr 1;109(7):2887-93
IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines.
Sankar S, Chan H, Romanow WJ, Li J, Bates RJ
Cellular signalling 2006 Jul;18(7):982-93
Cellular signalling 2006 Jul;18(7):982-93
Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells.
Osterlund P, Veckman V, Sirén J, Klucher KM, Hiscott J, Matikainen S, Julkunen I
Journal of virology 2005 Aug;79(15):9608-17
Journal of virology 2005 Aug;79(15):9608-17
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T
Nature immunology 2003 May;4(5):491-6
Nature immunology 2003 May;4(5):491-6
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
