BS7187

antibody from Bioworld Technology, Inc
Targeting: PAK4
Provider product page for BS7187
Western blot
Immunohistochemistry

Antibody data

Product number
BS7187 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PAK4 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PAK4.
Description
Three recently identified isoforms of serine/threonine kinases, designated Ï«PAK p68, ÉÇPAK p65 and ÎÛPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiaekinase STE20, involved in pheromone signaling. The Ï«, ÉÇ and ÎÛPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PAK4 protein structure - BS7187 shown in red.