abx001617

antibody from Abbexa
Targeting: PSMC2 MSS1, Nbla10058, S7
Provider product page for abx001617
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
abx001617 - Provider product page
Provider
Abbexa
Product name
26S Proteasome Regulatory Subunit 7 (PSMC2) Antibody
Antibody type
Polyclonal
Description
26S Proteasome Regulatory Subunit 7 (PSMC2) Antibody is a Rabbit Polyclonal antibody against 26S Proteasome Regulatory Subunit 7 (PSMC2). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µl
Concentration
> 1 mg/ml
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
PSMC2 protein structure - abx001617 shown in red.