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- Antibody Data
- Antigen structure
- References [4]
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- Product number
- MAB3587 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Carboxypeptidase E/CPE Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human Carboxypeptidase E/CPE in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) CPA1, rhCPA2, rhCPB1, or recombinant mouse CPA4 is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
P16870- Isotype
- IgG
- Antibody clone number
- 420709
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function.
A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.
An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.
NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway.
Cong L, Cheng Y, Cawley NX, Murthy SR, Loh YP
PloS one 2017;12(1):e0170169
PloS one 2017;12(1):e0170169
A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.
Cheng Y, Cawley NX, Yanik T, Murthy SR, Liu C, Kasikci F, Abebe D, Loh YP
Translational psychiatry 2016 Dec 6;6(12):e973
Translational psychiatry 2016 Dec 6;6(12):e973
An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.
Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP
The Journal of clinical investigation 2011 Mar;121(3):880-92
The Journal of clinical investigation 2011 Mar;121(3):880-92
NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway.
Carrel D, Du Y, Komlos D, Hadzimichalis NM, Kwon M, Wang B, Brzustowicz LM, Firestein BL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jun 24;29(25):8248-58
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jun 24;29(25):8248-58
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